TEMPO, FREE RADICAL
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Category:
Specialty Chemicals
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Product Profile
2,2,6,6-Tetramethylpiperidine-1-oxyl
Product Overview
TEMPO (2,2,6,6-Tetramethylpiperidine-1-oxyl) is a stable nitroxyl free radical widely recognized as one of the most efficient and selective oxidation catalysts in modern organic synthesis. It is supplied as an orange to red or reddish-brown liquid or solid and is extensively used in pharmaceutical, fine chemical, polymer, and specialty chemical industries.
Due to its exceptional selectivity, TEMPO is particularly effective in the oxidation of primary alcohols to aldehydes and secondary alcohols to ketones while minimizing unwanted side reactions. It is considered one of the most important oxidation catalysts in green chemistry and sustainable synthesis processes.
Applications
Organic Synthesis
TEMPO is widely used in selective oxidation and specialty organic synthesis.
| Application Area | Typical Uses |
|---|---|
| Selective Alcohol Oxidation | Oxidation of primary and secondary alcohols |
| Aldehyde Synthesis | Conversion of primary alcohols to aldehydes |
| Ketone Synthesis | Conversion of secondary alcohols to ketones |
| Fine Chemical Production | Used in high-value fine chemical manufacturing |
| Specialty Organic Synthesis | Applied in advanced organic synthesis processes |
Catalysis
| Application Area | Typical Uses |
|---|---|
| Oxidation Catalyst | Highly selective catalyst for oxidation reactions |
| Radical-Mediated Reactions | Used in nitroxyl radical chemistry |
| Green Chemistry Processes | Supports efficient and sustainable synthesis routes |
| Selective Oxidation Systems | Used in controlled oxidation processes |
| Industrial Catalysis | Applied in industrial catalytic applications |
Pharmaceuticals
| Application Area | Typical Uses |
|---|---|
| Pharmaceutical Intermediates | Used in the synthesis of pharmaceutical intermediates |
| API Synthesis | Applied in active pharmaceutical ingredient production |
| Drug Development | Used in research and development processes |
| Fine Chemical Manufacturing | Suitable for pharmaceutical fine chemical production |
Polymer & Materials Science
| Application Area | Typical Uses |
|---|---|
| Controlled Radical Polymerization | Used in controlled polymerization systems |
| Polymer Modification | Applied in polymer functionalization and modification |
| Functional Material Synthesis | Used in advanced material preparation |
| Surface Chemistry | Applied in surface modification and functionalization |
Physical & Chemical Properties
| Property | Value |
|---|---|
| Chemical Name | 2,2,6,6-Tetramethylpiperidine-1-oxyl |
| Common Name | TEMPO |
| CAS Number | 2564-83-2 |
| Molecular Formula | C₉H₁₈NO |
| Molecular Weight | 156.25 g/mol |
| Appearance | Orange to Red or Reddish-Brown Liquid/Solid |
| Specific Gravity, 25°C | 0.898 |
| Boiling Point | 193°C |
| Freezing Point | 35 – 38°C |
| Water Solubility | Slightly Soluble |
| Flash Point, Closed Cup | 67°C |
Specifications
| Item | Specification |
|---|---|
| Appearance | Orange to Red or Reddish-Brown Liquid/Solid |
| Purity, GC | ≥ 98.0 wt.% |
| Water Content, KF | ≤ 1.0 wt.% |
Packaging & Transportation
Standard Packaging
| Packaging Type | Net Weight / Description |
|---|---|
| Fiber Drum | 25 kg |
| Carton Drum | 25 kg |
| Drum | 50 kg |
| Customized Packaging | Available upon request |
Transportation
TEMPO is classified as dangerous goods and is suitable for transportation by sea, road, and rail. It should be handled, packed, stored, loaded, and transported according to applicable international hazardous chemical regulations.
Regulatory Information
| Item | Value |
|---|---|
| CAS Number | 2564-83-2 |
| IMDG Class | Class 8 |
| HS Code | 2933.39.90 |
Storage & Handling
Store TEMPO in a cool, dry, and well-ventilated area. Keep containers tightly sealed when not in use.
Protect the product from direct sunlight and excessive heat. Avoid contact with strong oxidizing agents and strong acids.
Keep away from open flames, sparks, and ignition sources. Use suitable storage conditions to maintain product stability and prevent contamination.
Health & Safety
Avoid inhalation of dust, vapors, or aerosols. Avoid direct contact with skin and eyes.
Wear appropriate personal protective equipment, including chemical-resistant gloves, safety goggles, and protective clothing during handling, transfer, and processing operations.
In case of skin or eye contact, rinse immediately with plenty of water for at least 15 minutes. If inhaled, move the affected person to fresh air and seek medical attention if necessary.
In case of ingestion, obtain immediate medical assistance.
Follow all applicable workplace safety procedures and consult the Safety Data Sheet before use.
Key Advantages
| Advantage | Description |
|---|---|
| Stable Radical Catalyst | Stable nitroxyl free-radical catalyst |
| High Selectivity | Highly selective oxidation performance |
| Alcohol Oxidation | Excellent conversion of alcohols to aldehydes and ketones |
| Green Chemistry Use | Widely used in green chemistry and sustainable synthesis |
| High Purity | Minimum 98.0% assay |
| Pharmaceutical Application | Suitable for pharmaceutical and fine chemical synthesis |
| Reliable Quality | Stable quality and industrial consistency |
| Flexible Packaging | Available in multiple packaging options |
Product Description
TEMPO (2,2,6,6-Tetramethylpiperidine-1-oxyl) is a high-purity stable nitroxyl radical catalyst widely used in selective oxidation reactions and advanced organic synthesis.
Renowned for its ability to efficiently convert primary alcohols into aldehydes with excellent selectivity, TEMPO has become a key catalyst in pharmaceutical manufacturing, fine chemical production, polymer chemistry, and green chemistry processes.
With reliable quality, high catalytic efficiency, and broad industrial applicability, TEMPO remains one of the most important oxidation catalysts used worldwide.