1,8-DIAZABICYCLO[5.4.0]UNDEC-7-ENE
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Category:
Specialty Chemicals
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Product Profile
Product Overview
1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) is a highly reactive bicyclic amidine compound widely recognized as a strong, non-nucleophilic organic base. It is extensively used in pharmaceutical synthesis, fine chemicals, catalyst systems, polymer chemistry, and epoxy curing applications.
DBU offers exceptional basicity while minimizing unwanted side reactions, making it a preferred reagent in modern organic synthesis. It is supplied as a clear, colorless to pale yellow liquid with excellent solubility and chemical stability.
Applications
Pharmaceuticals
DBU is widely used in the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients.
| Application Area | Typical Uses |
|---|---|
| Rupatadine | Used in pharmaceutical synthesis routes |
| Ruxolitinib | Used in API and intermediate production |
| Tipiracil | Applied in pharmaceutical manufacturing |
| Zonisamide | Used in specialty pharmaceutical synthesis |
| Pharmaceutical Intermediates | Used as a strong base in intermediate synthesis |
| API Manufacturing | Applied in active pharmaceutical ingredient production |
Organic Synthesis
| Application Area | Typical Uses |
|---|---|
| Non-Nucleophilic Base | Used as a strong organic base with low nucleophilicity |
| Condensation Reactions | Promotes efficient condensation processes |
| Elimination Reactions | Supports selective elimination reactions |
| Cyclization Reactions | Used in ring-forming synthetic processes |
| Deprotonation Reactions | Effective for proton abstraction reactions |
| Organic Intermediates | Used in fine chemical and specialty intermediate synthesis |
Catalysts & Ligands
| Application Area | Typical Uses |
|---|---|
| Catalyst Systems | Used in organic and specialty catalyst systems |
| Complexing Ligand | Functions as a ligand in selected chemical processes |
| Organometallic Chemistry | Applied in organometallic reaction systems |
| Specialty Chemicals | Used in specialty chemical manufacturing |
Polymers & Epoxy Systems
| Application Area | Typical Uses |
|---|---|
| Epoxy Curing Agent | Used in epoxy curing and hardening systems |
| Polyurethane Chemistry | Applied in polyurethane-related processes |
| Resin Modification | Used in resin systems and performance modification |
| Polymerization Processes | Supports selected polymerization applications |
Physical & Chemical Properties
| Property | Value |
|---|---|
| Chemical Name | 1,8-Diazabicyclo[5.4.0]undec-7-ene |
| Common Name | DBU |
| CAS Number | 6674-22-2 |
| Molecular Formula | C₉H₁₆N₂ |
| Molecular Weight | 152.24 |
| Appearance | Clear, Colorless to Pale Yellow Liquid |
| Specific Gravity, 20°C | 1.0190 |
| Boiling Point | 260°C |
| Water Solubility | Soluble |
| Flash Point, Closed Cup | 111°C |
Specifications
| Item | Specification |
|---|---|
| Appearance | Clear and Colorless to Pale Yellow Liquid |
| Purity | ≥ 98.0 wt.% |
| Water Content | ≤ 0.5 wt.% |
Packaging & Transportation
Standard Packaging
| Packaging Type | Net Weight / Description |
|---|---|
| Steel Drum | 200 kg |
| Drum | 220 kg |
| IBC Tank | 1000 kg |
| ISO Tank Container | Bulk Packaging |
| Bulk Shipment | Available for large-volume orders |
Transportation
DBU is classified as dangerous goods and is suitable for transportation by sea, road, and rail. It should be handled, loaded, transported, and stored according to applicable international hazardous chemical regulations.
Regulatory Information
| Item | Value |
|---|---|
| CAS Number | 6674-22-2 |
| UN Number | 2922 |
| IMDG Class | Class 3 |
| HS Code | 2933.59.90 |
Storage & Handling
Store DBU in tightly closed containers in a cool, dry, and well-ventilated area.
Avoid contact with copper and copper-containing alloys. Protect the product from direct sunlight, moisture, and excessive heat.
Keep away from ignition sources and incompatible materials. Ensure adequate ventilation during storage, transfer, sampling, and handling operations.
Maintain container integrity to prevent contamination.
Health & Safety
DBU may cause irritation to the skin, eyes, and respiratory system. Avoid direct contact with the product and prevent inhalation of vapors.
Wear appropriate personal protective equipment, including chemical-resistant gloves, safety goggles, and protective clothing.
In case of skin or eye contact, rinse immediately with plenty of water for at least 15 minutes. If inhaled, move the affected person to fresh air and seek medical attention if required.
In case of ingestion, obtain immediate medical assistance.
Key Advantages
| Advantage | Description |
|---|---|
| Strong Organic Base | Strong non-nucleophilic organic base |
| High Reactivity | Excellent reactivity with good selectivity |
| Pharmaceutical Use | Widely used in pharmaceutical synthesis |
| Catalyst Functionality | Effective catalyst and complexing ligand |
| Epoxy Application | Suitable for epoxy curing applications |
| High Purity | Minimum 98.0% assay |
| Flexible Packaging | Available in drum, IBC, ISO tank, and bulk packaging |
| Global Supply | Reliable quality and global supply capability |
Product Description
1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) is a high-performance bicyclic amidine base widely utilized in pharmaceutical manufacturing, organic synthesis, catalyst systems, and polymer chemistry.
Known for its strong basicity and non-nucleophilic characteristics, DBU enables efficient and selective chemical transformations in a wide range of industrial applications.
With high purity, excellent stability, and versatile functionality, DBU is an essential reagent for pharmaceutical, specialty chemical, and advanced materials production worldwide.