4-Methyl-2-pentanone (Methyl isobutyl ketone, MIBK)

CAS No.: 108-10-1
Synonyms / IUPAC Name: 4-Methyl-2-pentanone; Methyl isobutyl ketone (MIBK)
Molecular Formula: C₆H₁₂O
Molecular Weight: ~100.16 g/mol

Physicochemical Properties (Typical)

• Appearance: Colorless to almost colorless clear liquid
• Odor: Characteristic ketone odor
• Melting / Freezing Point: Approx. –85 °C
• Boiling Point: Approx. 115-117 °C
• Density (20 °C): ~0.80 g/cm³
• Refractive Index (n²⁰ᴰ): ~1.395
• Solubility in Water: Slightly soluble (~19 g/L at 20 °C)
• Flash Point (closed cup): ~14-17 °C
• Explosive / Flammable Limits (in air): Lower ~1.2-1.4% v/v, Upper ~7.5-8% v/v
• Vapour Density: ~3.5 (air = 1)

Purity & Quality Standards

• Purity (GC): ≥ 99.0% (typical reagent grade)
• Moisture Content: ≤ 0.05% for high-purity solvents
• Non-volatile Residue: Minimal (≤ 0.001%)
• Documentation: Certificate of Analysis (COA) and Safety Data Sheet (SDS) provided

Applications / Uses

• Industrial solvent for resins, coatings, inks, adhesives
• Extraction solvent in chemical processes
• Intermediate for synthesis in fine chemicals and pharmaceuticals
• Used in formulations requiring moderate volatility and good solvent power

Safety & Handling

• Hazard Classification: Highly flammable liquid & vapour
• Health Hazards:
  • Inhalation may cause dizziness, headache, respiratory irritation
  • Skin contact may cause dryness or irritation; absorption through skin possible
  • Eye contact causes serious irritation
• Precautions:
  • Use in well-ventilated area
  • Wear protective gloves, eyewear, and protective clothing
  • Keep away from heat, sparks, open flame, and hot surfaces
  • Ground/bond containers and equipment during transfer; use non-sparking tools
• Incompatibilities: Strong oxidizers, strong bases, acids, amines; plastics may be attacked
• First Aid Measures:
  • Inhalation: Move to fresh air; keep at rest and comfortable for breathing
  • Skin: Wash with soap and water; remove contaminated clothing
  • Eyes: Rinse thoroughly with water for several minutes
  • Ingestion: Rinse mouth; do not induce vomiting; seek medical advice

Packaging & Storage

• Packaging: Sealed solvent-compatible containers (e.g., metal drums or lined steel)
• Storage Conditions: Cool (<30 °C), dry, well-ventilated area away from direct sunlight and ignition sources
• Container Closure: Keep tightly closed when not in use to prevent vapour release
• Shelf Life: Typically 12–24 months under recommended conditions