DIISOPROPYL ETHYLAMINE
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Category:
Amine Derivatives
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Product Profile
Product Overview
Diisopropylethylamine (DIPEA), also known as Hünig’s Base, is a sterically hindered tertiary amine widely used as a non-nucleophilic organic base in pharmaceutical, agrochemical, and fine chemical synthesis.
Due to its strong proton-accepting ability, low nucleophilicity, and excellent selectivity, DIPEA is a key reagent in modern organic synthesis, particularly in peptide coupling reactions and API manufacturing.
Applications
Pharmaceutical Industry
- Antibiotics synthesis
- Antihistamines production
- Anti-diabetic drugs
- Anti-cancer agents
- Antibacterial drugs
- Active pharmaceutical ingredients (APIs)
- Peptide synthesis intermediates
Agrochemicals
- Fungicide intermediates
- Herbicide synthesis
- Crop protection chemicals
- Agrochemical formulations
Fine Chemicals
- Organic synthesis reagent
- Acid scavenger
- Coupling reaction base
- Catalyst system component
- Specialty chemical manufacturing
Physical & Chemical Properties
| Property | Value |
|---|---|
| Chemical Name | Diisopropylethylamine |
| Synonyms | DIPEA, Hünig’s Base |
| CAS Number | 7087-68-5 |
| Molecular Formula | C₈H₁₉N |
| Molecular Weight | 129.20 |
| Appearance | Clear to pale yellow liquid |
| Boiling Point | 125–128°C |
| Flash Point | 8–10°C |
| Density (20°C) | 0.74–0.76 |
| Refractive Index (20°C) | 1.413–1.415 |
| Water Solubility | Sparingly soluble |
Specifications
| Item | Specification |
|---|---|
| Appearance | Clear colorless to pale yellow liquid |
| Purity (GC) | ≥ 99.50 wt.% |
| Water Content | ≤ 0.20 wt.% |
| Total Impurities | ≤ 0.30 wt.% |
Packaging & Transportation
Packaging Options
- 180 kg steel drum
- 190 kg steel drum
- 200 kg steel drum
- ISO tank container
- Bulk tank truck
Transportation
- Classified as Dangerous Goods (Class 3)
- UN Number: 2733
- Compliant with international hazardous chemical regulations
- Suitable for sea, road, and rail transport
- Professional logistics handling available
Storage & Handling
- Store in tightly sealed containers
- Keep in a cool, dry, well-ventilated area
- Avoid heat, sparks, and ignition sources
- Protect from direct sunlight and moisture
- Avoid contact with copper and copper alloys
- Ensure good ventilation during handling
- Use appropriate PPE during operation
Health & Safety
- May cause irritation to skin, eyes, and respiratory system
- Avoid inhalation and direct contact
- In case of contact, rinse immediately with water for at least 15 minutes
- If inhaled, move to fresh air and seek medical attention
- If swallowed, seek immediate medical assistance
- Always wear protective equipment during handling
Key Advantages
- High purity grade (≥99.5%)
- Excellent non-nucleophilic organic base
- Ideal for peptide coupling reactions
- Widely used in API and pharmaceutical synthesis
- Low water solubility for easy separation/recovery
- Stable quality and consistent performance
- Available in drum, bulk, and ISO tank
- Global hazardous chemical logistics support
Product Summary
Diisopropylethylamine (DIPEA) is a high-performance sterically hindered tertiary amine widely used as a non-nucleophilic base in pharmaceutical, agrochemical, and fine chemical synthesis. Known as Hünig’s Base, it plays a critical role in peptide synthesis and API manufacturing due to its excellent selectivity, stability, and reaction efficiency.